Alzheimer’s and Parkinson’s disease (AD & PD) are common forms of a wide spectrum of neuro-cognitive diseases broadly labelled Dementia. Dementia is now the leading cause of Disability in the over 65’s. It is the 2nd leading cause of death in Australia and the leading cause of death for women, now surpassing heart disease. 3 in 10 people > 85yrs and 1 in 10 > 65yrs have Dementia. These numbers are on the increase and sadly include younger onset Dementia. (Dementia Australia report, Jan 2018)
These debilitating and soul destroying conditions, erode the very fabric of the sufferer and can devastate not only the individual but close family, their loved ones and friends. Quality of life decays.
Ageless NAD has drawn from international scientific trials, both animal and human, as well as significant anecdotal evidence from our international colleagues to create tailored NAD+ treatment prescription to address early cognitive decline. Clinical trials for both Alzheimer’s and Parkinson’s disease are highly encouraging and demonstrate a slowing and even reversal of symptoms using NAD+.
If you, or a loved one has been diagnosed with a neurodegenerative condition we refer you to studies related to NAD+ and the treatment of Dementias.
1) Human Alzheimer’s study : Treatment of Alzheimer’s disease with stabilized oral NAD: a randomised, double blind study
“after 6 months of treatment, subjects treated showed no evidence of progressive cognitive deterioration and had significantly higher total scores” on multiple medical assessment tools. Subscales revealed significantly better performance on verbal fluency, visual construction activity and abstract verbal reasoning
2) NAD+ & Parkinson’s Study. The NAD+ precursor NR (that converts to NAD+ in the body) rescues Mitochondrial defects and neuronal loss in iPSC and fly models of Parkinson’s disease:
“Mitochondrial dysfunction is emerging as a key in PD. We report that increasing NAD+ significantly ameliorates mitochondrial function in patient neurones. Our findings suggest that NAD+ as a viable clinical avenue for neuroprotection in PD and other neurodegenerative diseases.”
3) Treating Dementia with Vitamin B3 and NADH, a study but Chief Naturopathic Medical Officer, Canadian College of Medicine.
"Dementia is debilitating and progressive, the most common type is Alzheimer’s disease followed by vascular types. Our current crop of treatments show limited value. Niacin is a worthwhile consideration, research has shown that the risks of AD increase with insufficient Niacin. Therapeutic benefits have been documented when patients receive optimum daily doses. NADH is a safe an effective treatment for AD."
4) NAD+ & Alzheimers Study. The NAD+ precursor NR (that converts to NAD+ in the body) restores cognition in Alzheimer’s mouse models:
“our studies suggest that treatment with NR might benefit AD cognitive function and synaptic plasticity, thus preventing A beta production in the brain”
5) NAD+ and NADH in brain functions, brain diseases and brain aging.
“our latest studies suggest that NAD+ can markedly decrease ischemic brain injury. Based on this information, it is proposed that NAD+ and NADH are fundamental mediators of brain functions, brain senescence and multiple brain diseases”
There is real promise with NAD+ treatment for AD + PD and to understand this we need to understand the pathogenesis and development of neurodegenerative disease. As we age a number of environmental factors come into play including diet, exercise, family and work stress among others.
Protein fragments called beta amyloid plaques (BAP’s) are one of the hallmarks of Alzheimer’s disease. It is the build up of these sticky plaques (also known as Senile Plaques or SP’s) outside of the cells in the brain and additionally neurofibrillary tangles (NFT’s) that occur inside the cells in the brain that disrupt communication, the neurons & synapses and eventually causes neuro-degeneration and gross atrophy of the brain.
Intracellular and extracellular disruption of neurons in the brain through BAP’s or SP’s and NFT’s occur over time with AD,PD and dementia.
The medical and social cost of this disease is enormous. To date, the potential to reduce its occurrence and treat ongoing disease is uninspiring. The “evidence based” advice is well documented and has not changed for some time.
Eat a well balanced diet, quality sleep, reduce alcohol and toxin consumption and engage in regular high and low intensity exercise whilst living a low stress lifestyle is the best means to prevent Alzheimer’s and neuro-degenerative Dementia.
This is all very well but this simple advice can often be difficult to apply in our busy modern lives.
Considering the lack of effective treatments, prevention is far better than cure NAD+ may hold the key to future generations protection via NAD+ oral supplements and intravenous NAD+ infusions.
We invite you and your loved one to a confidential consultation with our Medical Consultant at Ageless NAD either via audio/visual call or in clinic at our 17 Hollywood Avenue, Bondi Junction, Sydney clinic.
NAD+ stands for Nicotinamide Adenine Dinucleotide.
NAD+ is a molecule that is found in every cell in your body and plays a role in regulating normal cellular function through providing mitochondrial energy supply. The ongoing energy supply to mitochondria (the batteries of our cells) via NAD+ provides the ability for every human cell to communicate and instigate repair and rebuild after normal environmental insult. Eating, breathing, psychological stress, & chemical stress (alcohol, pollution, drugs) all cause stress to cells which cause DNA damage that requires higher levels of NAD to ensure repair.
Thus whenever there is tissue or even psychological injury (sibling parental or friend death/injury, work related psychological trauma or relationship breakdown), NAD+ is required to repair injured body or neuronal tissue.
Increasing environmental/ psychological stress causes increasing requirement of NAD+. Increasing need of NAD combined with diminishing production capability (normal ageing) creates a condition known as NAD STEAL.
NAD STEAL results where the amount of ageing/ environmental damage (physical or environmental trauma) INCREASES and natural NAD+ production DECREASES, usually attributed to normal ageing and increased age related inflammation.
The result is, after the age of 40-50, an intrinsically reducing level of natural NAD+ production, combines with increased need for NAD+ due to environmental damage.
When the NAD+ potential of an individual cell reduces so it cannot maintain intracellular activity and intercellular communication the cell will mark itself for death, a recognised process called apoptosis. The end result is increased DNA damage, significant reduction of the functional mitochondria in the cell, apoptosis (cellular loss) and accelerated ageing.
This essential molecule NAD+, ultimately determines how quickly not only our individual cells age but more importantly how the human body ages.
Poor mitochondria function and cellular decline with ageing results in humans experiencing increased lethargy, muscle loss, peripheral fat gain, increased inflammatory pain and cellular dysfunction leading to cellular decay…. in simple terms, the acceleration of the ageing process.
NAD+ helps in the battle against ageing by activating enzymes called "SIRTUIN" and "PARPS" which are essential in maintaining DNA repair which restore normal cellular DNA and normal cellular function.
Maintaining highest level NAD+ levels is key to supporting DNA repair in combination with prevention against age / inflammatory related disease. Enhancing NAD+ levels reduce NAD STEAL and neurodegenerative decline.